Researchers identified 11 new genes that affect the risk for Alzheimers disease. The findings point to novel targets for preventing or delaying the disease.
Alzheimer’s disease is the most common cause of dementia in older adults. It affects more than 5 million Americans. A hallmark of the disease is the abnormal accumulation of amyloid protein in the brain. Until 2009, variants in only one gene, APOE, had been identified as a risk factor for late-onset Alzheimer’s disease, the most common form of the disorder. The list of known genetic risk factors has since grown to include several others.
Large-scale analyses are needed to gain the statistical power to identify additional genetic risk factors. S